第07回 内藤コンファレンス

糖脂質･スフィンゴ脂質の構造と機能

組織委員

セッション

Session1
Cell Adhesion and Cellular Processes [I]

1. Carbohydrate expression during development of the rodent olfactory system

   [G. A. Schwarting]

   E. K. Shriver Center for Mental Retardation, USA,

2. Induction of glycosphingolipid biosynthesis and neurite outgrowth of primary cultured neurons by L-threo-1-phenyl-2-decanoylamino-3-morpholino-1 propanol (L-PDMP).

   [J. Inokuchi]

   Seikagaku Corporation,

3. Cell remodeling and phenotypic changes of tumor cells due to overexpression of the N-acetylglucosaminyltransferase III gene

   [N. Taniguchi]

   Osaka University Medical School,

4. Regnlation of expression of carbohydrate ligands for selectins in malignant cells

   [R. Kannagi]

   Aichi Cancer Research Institute,

5. Structure and fumction of ganglioside-hydrolyzing sialidase

   [T. Miyagi]

   Miyagi Cancer Center Research Institute,

6. Anti-glycolipids antibodies in motor neuropathies

   [N. Baumann]

   Salpetriere Hospital, France,

7. Preparation of peptides which mimic carbohydrate structure of glycosphingolipid by phage library and their properties

   [T. Taki]

   Tokyo Medical and Dental University,

Session2
Recognition

1. Lipid modulation of glycolipid receptor function‐an approach to soluble mimics.

   [C. A. Lingwood]

   Hospital for Sick Children, Canada,

2. A streptavidin-based neoglycoprotein as a multivalent glycoprobe

   [Y. Hashimoto]

   Tokyo Metropolitan Institute of Medical Science,

3. Sulphatide in islets cells-Its potential role in insulin secretion

   [P. Fredman]

   University of Goteborg, Sweden,

4. Myelin-associated glycoprotein: A brain lectin recognizing nerve cell gangliosides

   [R. L. Schnaar]

   The Johns Hopkins University, USA,

5. Natural and synthetic gangliosides reveal distinct binding specificities of I-type lectins

   [B. E. Collins]

   The Johns Hopkins University, USA,

6. Minor brain neutral glycosphingolipids; cellular topography and alterations in dys‐and demyelination

   [E. L. Hogan]

   Medical University of South Carolina, USA,

Session3
Transmembrane Signaling [I]

1. Molecular mechanisms of TNF-induced activation of neutral sphingomyelinase

   [M.Kronke]

   University of Kiel, GeImany,

2. Acid sphingomyelinase deficient human lymphoblasts and mice are defective in radiation-induced apoptosis

   [R. N. Kolesnick]

   Memorial Sloan-Kettering Cancer Center, USA,

3. The catalytic estelification of ceramide to form l-O-acylceramjde by a novel phospholipase

   [J. A. Shayman]

   University of Michigan Medical Center, USA,

4. Ceramide: An intracellular stress signal

   [Y. A. Hannun]

   Duke University Medical Center, USA,

5. Mechanisms of apoptosis induction by sphingosine, N, N -dimethylsphingosine, and epidemlal growth factor in solid tumor cells: A possible involvement of mitogen-activated protein kinase in apoptotic signaling

   [Y. Igarashi]

   Fred Hutchinson Cancer Research Center, USA,

6. Mechanism of sustained accumulation of ceramide in apoptosis

   [G. Dawson]

   University of Chicago, USA,

Session4
GlycobioIogy and Glycotechnology

1. Sialoglycoconjugates, synthesis and biological importance

   [M. Kiso]

   Gifu University,

2. Novel variant pathway in the synthesis of protein- and lipid-1inked, complex-type oligosaccharides. Lessons we learn from invertebrates.

   [D. H. van den Eijnden]

   Vrije University, Amsterdam, The Netherlands,

3. Orthogonal glycosylation for the rapid oligosaccharide assembly

   [O. Kanie]

   The Institute of Physical and Chemical Research, RIKEN,

4. Specificities of GM2 activator protein and GM2A protein.

   [S. -C. Li]

   Tulane University School of Medicine, USA,

5. Oligosaccharide libraries.

   [O. Hindsgaul]

   University of Alberta, Canada,

Session5
Transmembrane Signaling [II]

1. Free sphingoid base metabolism in cell signaling and disease.

   [A.H Merrill, Jr.]

   Emory Univ. Center for Nutrition & Health Sciences, USA,

2. Mutant and inhibitor studies of sphingolipid biosynthesis

   [S. M. Mandala]

   Merck Research Laboratories, USA,

3. Generation and Functions of Lysosphingolipids

   [M. Ito]

   Kyushu University,

4. Modulation of neurotrophic factor receptor by ganglioside-Novel interaction of ganglioside GM1 and Trk receptor.

   [T. Mutoh]

   Fukui Medical School,

5. Regulation of apoptosis by sphingosine in a mouse cytotoxic T cell line, CTLL-2

   [Y. Kozutsumi]

   Kyoto University,

6. The role of sphingosine-1-phosphate in cell growth and apoptosis.

   [S. Spiegel]

   Georgetown University Medical Center, USA,

Session6
Control of Cell Growth

1. Extended globo-series glycosphingolipids that mediate cell adhesion and signaling.

   [S. Hakomori]

   Pacific Northwest Research Foundation, USA,

2. Multiple fimctions of Lex structures during mouse embryogenesis.

   [T. Muramatsu]

   Nagoya University School of Medicine,

3. Lactosylceramide and shpingomyelinase as mediators of cell proliferation and cell death.

   [S. Chatterjee]

   The Johns Hopkins University, USA,

4. Expression, regulation and function of sulfoglucuronyl (HNK-1) carbohydrate in the developing nervous system.

   [F. B. Jungalwala]

   E. K. Shriver Center for Mental Retardation, USA,

5. Sphingolipids and neuronal growth

   [H. Futerman]

   Weizmann lnstitute of Science, Israel,

Session7
Molecular Approach of Glycosyltransferases

1. Analysis of fucosyl-transferase VII deficient mice

   [P. L. Smith]

   University of Michigan Medical Center, USA,

2. Mutant analysis of human fucosyltransferase genes and correlation with cancer incidence.

   [H. Narimatsu]

   Soka University,

3. Three active α1, 2-fucosyl transferase genes exist in rabbit.

   [S. Hitoshi]

   University of Tokyo,

4. Ganglioside biosynthesis and α2,8-sialyltransferases.

   [S. Tsuji]

   The Institute of Physical and Chemical Research, RIKEN,

5. Glucosylceramide synthase: Biological significance of glycosylation of ceramide.

   [Y. Hirabayashi]

   The Institute of Physical and Chemical Research, RIKEN,

6. Ganglioside GM3 binds to vimentin and protects it from proteolysis in human leukemia cells.

   [K. Honke]

   Osaka Medical Center for Matemal and Child Health,

7. HNK-1epitope and glucuronyl transferase.

   [T. Kawasaki]

   Kyoto University,

Session8
Trafficking

1. Sphingolipid transport pathways to the two surfaces of epithelial cells: Involvement of multidrug resistance P-glycoproteins?

   [G. van Meer]

   Utrecht University Medical School, The Netherlands,

2. Ganglioside domains and caveolae.

   [M. Masserini]

   University of Milan, Italy,

3. Incorporation of sugars into glycosphingolipids (GSL) occurs predominantly by recycling pathways

   [B. K. Gillard]

   Baylor College of Medicine, USA,

4. Evidence for postendocytotic transport of short chain glycosphingolipids from lysosomes to the Golgi apparatus in human skin fibroblasts, rat neuroblastoma cells and rat intestinal epithelial cells.

   [G. Schwarzmann]

   Institute for Organic Chemistry and Biochemistry of the University of Bonn,Germany,

5. Consequences and therapeutic prevention of intercellular transfer of tumor gangliosides.

   [S. Ladisch]

   Children's National Medical Center, USA,

6. Release of soluble forms of glycosyltransferases

   [W. W. Young, Jr.]

   University of Louisville, USA,

Session9
Gene-Manipulation of Glycolipid Metabolism

1. Gene manipulation of ganglioside synthases in cellnlar and experimental animal levels.

   [K. Furukawa]

   Nagasaki University School of Medicine,

2. Maturation of sphingolipid activator proteins and glycolipid catabolism in k. o. mice.

   [K.Sandhoff]

   Institute for Organic Chemistry and Biochemistry of the University of Bonn, Germany,

3. Myelination in the absence of galctocerebroside and sulfatide.

   [B. J. Popko]

   The University of North Carolina, USA,

4. Phenotype of arylsulfatase A deficient mice: relationship to human metachromatic leukodystrophy.

   [V. Gieselmann]

   Chritian-Albrechts-Universitat Kiel, Germany,

5. Modeling the sphingolipidoses: GM2 gangliosidoses and Gaucher disease.

   [R. Proia]

   National Institute of Health, USA,