第11回 内藤コンファレンス

構造ゲノム科学:創薬への新しい道

組織委員

セッション

SessionA
From Genome to Structure

1. Structural Genomics - Mapping the Protein

   [Chris Sander]

   Millennium Predictive Medicine, USA

2. Structural Genimics of a Hyperthermophile: a Pilot Test

   [Sung-Hou Kim]

   Dept. of Chemistry and Lawrence Berkeley Natonal Laboratory, University of California, Berkeley, USA

3. Structural and Functional Genomics of Extreme Thermorphile

   [Seiki Kuramitsu]

   Dept. of Biology, Graduate School of Science, Osaka University, Japan

4. Automated Analysis of Protein NMR Spectra: Prognosis for Structural and Functional Genomics

   [Gaetano T. Montelione]

   Molecular Biology and Biochemistry Center for Advanced Biotechnology and Medicine, Rutgers University, USA

5. 3D Modeling and the Applications

   [Haruki Nakamura]

   Research Center for Structural Biology, Institute for Protein Research, Osaka University, Japan

SessionB
Functional Genomic

1. Mouse Genome Encyclopedia

   [Yoshihide Hayashizaki]

   Genomic Sciences Laboratory, RIKEN Tsukuba Life Science Center, Japan

2. Whole Genome analysis

   [Joseph DeRisi]

   Dept. of Biochemistry and Biophysics, University of California, San Francisco, USA

3. Using Expression Profiles to Follow Target Activities and Enable

   [Stephen H. Friend]

   Rosetta Inpharmatics, USA

4. Saturation Gene Trapping, Functional Genomics, and Drug Target Validation

   [Authur T. Sands]

   Lexicon Genetics Incorporated, USA

SessionC
Structural Biology of Infectious Agents

1. Crystallographic Study of HIV gp120: Viral Evasion Mechanism of the Immune Response

   [Wayne A. Hendrickson]

   Dept. of Biochemistry & Molecular Biophysics, College of Physician & Surgeons of Columbia University, USA

2. New Drugs for Influenza - an Example of Drug Design Against a Moving Target

   [Peter M. Colman]

   Biomolecular Research Institute, Australia

3. Crystallographic Study of HIV Reverse Transcriptase towards Drug Design

   [David Stuart]

   Laboratory of Molecular Biophysics, Oxford University, UK

4. New NMR Techniques for Studies of Prion Proteins

   [Kurt Wuthrich]

   Institute for Molecularbiology and Biophysics, ETH, Switzerland

SessionD
Proteins that Bind DNA

1. Crystal Structures of Human Topoisomerase 1 DNA Complexes and a Proposed Binding Mode of the Anti-Cancer Drug Camptothecin

   [Matthew R. Redinbo]

   Dept. of Chemistry, University of North Carolina, USA

2. Orphan Nuclear Receptors in Drug Discovery

   [Steven A. Kliewer]

   Dept. of Molecular Endocrinology, Glaxo Wellcome Research and Development, USA

3. Structural Biology of DNA Homologous Recombination

   [Kosuke Morikawa]

   Dept. of Structural Biology, Biomolecular Engineering Research Institute, Japan

4. Helix-turn-helix Variants in Telomeric Proteins and Transcription Factors

   [Yoshifumi Nishimura]

   Graduate School of Integrated Scinence, Yokohama City University, Japan

SessionE
COX-2 Inhibitors as Examples

1. Strucrural and Functional Apploaches to the Development of Novel COX-2 Inhibitors

   [Lawrence J. Marnett]

   Dept. of Biochemistry and Chemistry, Center in Molecular Toxicology, and The Vanderbilt-Ingram Cancer Center, Vanderbil University School of Medicine, USA

2. The Structural Basis for Selectivity of COX-2 Inhibitors

   [Michelle F. Browner]

   Molecular Structure Department, Roche Bioscience, USA

3. COX-2 Inhibitors and Colon Tumorigenesis

   [Makoto Mark Taketo]

   Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

4. Prostanoid Receptor Genes Knockout Mice

   [Shu Narumiya]

   Dept. of Pharmacology, Kyoto University Faculty of Medicine, Japan

SessionF
G Protein - Coupled Receptors

1. Discovery of Ligands for Orphan G Protein-coupled Receptors: Prolactin-releasing Peptide and Apelin

   [Haruo Onda]

   Discovery Research Laboratories 1, Pharmaceutical Discovery Division, Takeda Chemical Industries, Ltd., Japan

2. Discovery and Function of Orexins and Orexin Receptors

   [Masashi Yanagisawa]

   Howard Hughes Medical Institute and Department of Molecular Genetics,University of Texas Southwestern Medical Center, USA

3. Crystallographic Study of a Trimeric G-protein

   [Paul B. Sigler]

   Dept. of Molecular Biophysics and Biochemistry, Yale Unieversity, USA

4. Cell Signaling Mechanisms Involving Ras-family Proteins

   [Shigeyuki Yokoyama]

   The Unversity of Tokyo, RIKEN, Wako, Japan