第15回 内藤コンファレンス

難病の分子生物学 [III]

組織委員

セッション

SessionA
Protein Modification and Neurodegeneration

1. The Ubiquitin Proteasome Pathway in the pathogenesis of Neurogenerative Disease

   [Ron R. Kopito]

   Department of Biological Sciences, Stanford University, USA

2. Synuclein: the Good, the Bad and the Neurodegenerative

   [John Q. Trojanowski]

   Center for Neurodegenerative Disease Research, University of Pennsylvania, Department of Pathology and Laboratory Medicine, USA

3. The Role of the Ubiquitin - Proteasome Pathway in the Protein Quality Control of the Cell

   [Keiji Tanaka]

   Department of Molecular Oncology, The Tokyo Metropolitan Institute of Medical Sciences, Japan

4. Familial Parkinson's Disease and Endoplasmic Reticulum (ER) Stress

   [Ryosuke Takahashi]

   Laboratory for Motor System Neurodegeration, RIKEN Brain Science Institute, Japan

5. Deficient GluR2 mRNA Editing Causes AMPA Receptor-Mediated Neurotoxicity in Amyotrophic Lateral Sclerosis

   [Shin Kwak]

   Department of Clinical Neurology and Neoruscience, Graduate School of Medicine, The University of Tokyo, Japan

SessionB
Postgenomic Approaches to Multifactorial Neurological Diseases and Autoimmune Disorders

1. Multiple Sclerosis as a Polygenic Disease

   [Stephen J. Sawcer]

   University of Cambridge Neurology Unit, Addenbrooke's Hospital, UK

2. The Genetics of Late Onset Alzheimer Disease

   [Margaret A. Pericak-Vance]

   Duke University Medical Center for Human Genetics, USA

3. Molecular Genetic Studies of Schizophrenia: Complexities, Difficulties and New Directions

   [Yuji Okazaki]

   Department of Psychitry, Mie University School of Medicine, Japan

4. Toward Identification of Susceptibility Genes for Sporadic Parkinson's Disease

   [Tatsushi Toda]

   Department of Post-Genomics and Diseases, Osaka Unviersity Graduate School of Medicine, Japan

5. Molecular Genetics Approach for Sporadic Amyotrophic Lateral Sclerosis

   [Shoji Tsuji]

   Department of Newrology, Niigata University / Department of Neurology, Graduate School of Neducine, The University of Tokyo, Japan

SessionC
Novel Strateriges for Neurodegerative Disease

1. Engineering Antibodies for Huntington's Disease Therapies

   [Anne Messer]

   New York State Department of Health, USA

2. In vitro and In vivo Antisense Studies of Huntingtons Disease

   [Bjarke Naver]

   Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark

3. Therapeutic Approach for Spinal and Bulbar Muscular Atrophy Based on its Molecular Pathogenesis

   [Gen Sobue]

   Department of Neurology, Nagoya University Graduate School of Medicine, Japan

4. Therapeutic Approaches in Prion Disease

   [Kiyotoshi Kaneko]

   Department of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan

5. Gene Transfer of HGF in the Nervous System Retards Disease Progression and Prolongs Life Span of a Transgenic Mouse Model of ALS

   [Hiroshi Funakoshi]

   Division of Moelcular Regenerative Medicine, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Japan

SessionD
Novel Desease - associated Genes as Drug Discovery Targets

1. Discovery of Ghrelin and its Physiological Significance

   [kenji Kanagawa]

   Department of Biochemistry, National Cardiovascular Center Research Institute, Japan

2. Hematopoietic Stem Cells Differentiate into Smooth Muscle Cells That Contribute to Vascular Diseases

   [Masataka Sata]

   Department of Cardivascular Medicine, The University of Tokyo Graduate School of Medicine, Jpana

3. Aβ Metabolism and Alzheimer's Disease

   [Takaomi Saido]

   Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Japan

4. Klotho: A Fundamental Regulator of Calcium Homeostasis

   [Yo-ichi Nabeshima]

   Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto Univesity, Japan

SessionE
Regeneration and Gene Therapy of Intractable Disease

1. Differentiation of Stem Cells into Insulin Producing Cells

   [Suheir Assady]

   Rambam Medical Center and the Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Israel

2. Gene and Protein Base Therapies for Arthritis: Pre-clinical and Clinical Studies

   [Paul D. Robbins]

   Department of Molecular Genetics and Biochemistry, Univesity of Pittsburgh School of Medicine, USA

3. Rapid Identification of Functional Genes in the Post-Genome Era

   [Kazunari Taira]

   Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Japan

4. Molecular Basis of Reparative Responses in the Defects of Articular Cartlilage and Bone

   [Yuji Hiraki]

   Department of Molecular Interaction and Tissue Engineeing, Institute for Frontier Medical Sciences, Kyoto University, Japan

5. Suppression of Arthritis by Forced Expression of Cyclin-dependent Kinase Inhibitor Genes into the Joints

   [Nobuyuki Miyasaka]

   Department of Bioregulatory Medicine & Rheumatology, Graduate School, Tokyo Medical & Dental University, Japan