第31回 内藤コンファレンス

糖鎖の発現と制御 [II] 代謝物、ストレス応答、マイクロドメインと展望

組織委員

セッション

Plenary Lecture 1

1. Structure and function of lipids in membrane proteins

   [Tomitake TSUKIHARA]

   Department of Life Science, University of Hyogo, Japan

Session1
Plenary Lecture 2

1. Post-translational glycosylation: Challenges and opportunities

   [Chi-HueyWONG]

   Academia Sinica, Taiwan

SessionA
Revisit to glycan metabolism

1. Sialometabolome in health and disease

   [Ken KITAJIMA]

   Bioscience and Biotechnology Center, Nagoya University, Japan

2. Distinct functional roles between ganglioside sialidases Neu3 and Neu4

   [Taeko MIYAGI]

   Division of Cancer Glycosylation Research, Tohoku Pharmaceutical University, Japan

3. Development of new enzyme replacement therapy for Fabry disease based on molecular designing

   [Hitoshi SAKURABA]

   Departments of Analytical Biochemistry and Clinical Genetics, Meiji Pharmaceutical University, Japan

4. Functional roles of O-GlcNAc modification

   [JinWon CHO]

   Department of Integrated OMICS for Biomedical Science,Yonsei University, Korea

5. Using automated oligosaccharide synthesis to elucidate the basis of infectious disease mechanisms

   [Peter H. SEEBERGER]

   Max Planck Institute of Colloids and Interfaces and Free University, Germany and The Burnham Institute, USA

6. Novel strategy for dynamic tracing of UDP-GlcNAc metabolism-Involvement of nucleotide sugars in glucose metabolism disorders

   [Kazuki NAKAJIMA]

   Systems Glycobiology Research Group, RIKEN Advanced Science Institute, Japan

7. Sulfation patterns of chondroitin sulfate proteoglycans regulate critical period plasticity in the visual cortex

   [Shinji MIYATA]

   Department of Biochemistry, Kobe Pharmaceutical University, Japan

SessionB
Glycans in stress response

1. Posttranslational glycosylation: A mechanism to enhance glycoprotein quality control

   [Reid GILMORE]

   Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, USA

2. Role of autophagy in the catabolism of sialylated oligosaccharides in mammalian cells

   [Tadashi SUZUKI]

   Glycometabolome Team, RIKEN Advanced Science Institute, Japan

3. Lectins and enzymes that regulate the mammalian glycoprotein quality control

   [Nobuko HOSOKAWA]

   Institute for Frontier Medical Sciences, Kyoto University, Japan

4. Involvement of sphingolipids in phosphorylation and degradation ofYpk1 in the stress response of yeast

   [Yasunori KOZUTSUMI]

   Laboratory of Membrane Biochemistry and Biophysics, Graduate School of Biostudies, Kyoto University, Japan

5. Siglec-dependent cross-talk between the innate and adaptive immune systems

   [Paul R. CROCKER]

   Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, UK

6. Hypoxia-induced Sialyl-Tn carbohydrate antigen expression facilitates tumor metastasis

   [Kazuaki OHTSUBO]

   Systems Glycobiology Research Group, RIKEN Advanced Science Institute, Japan

7. Induction of autophagy by chitobiose and its derivatives

   [Hisashi ASHIDA]

   Graduate School of Biostudies, Kyoto University, Japan

SessionC
Dynamics of membrane microdomains and its physiopathological implications

1. Membrane microdomain ortho-signaling therapy

   [Jin-ichi INOKUCHI]

   Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, Japan

2. The lipid phase problem and the induction of a lipidosis in the endolysosomal system

   [Konrad SANDHOFF]

   LIMES co Kekulé-Institut, University of Bonn, Germany

3. Plasma membrane glycohydrolases and new strategies for medical diagnosis and therapeutic treatments

   [Sandro SONNINO]

   Department of Chemistry, Biochemistry, and Biotechnologies for Medical Sciences, University of Milan, Italy

4. Role of glycolipids in innate immune responses of phagocytes

   [Kazuhisa IWABUCHI]

   Infection Control Nursing, Graduate School of Health Care and Nursing, Juntendo University, Japan

5. Ganglioside-induced conformational change of amyloid β-protein as an initial step in the process of Alzheimer disease

   [KatsuhikoYANAGISAWA]

   Research Institute, National Center for Geriatrics and Gerontology, Japan

6. Negative regulation of LPS signals by globo-series glycosphingolipids

   [Yuji KONDO]

   Department of Biochemistry II, Nagoya University School of Medicine, Japan

7. A new EMARS system using HRP expressed by gene manipulation technology

   [ArisaYAMAGUCHI]

   Kochi System Glycobiology Center, Kochi University Medical School, Japan

SessionD
New approaches to glycobiology

1. Galectin-binding to specific glycoforms of serum glycoproteins: Mechanisms of selectivity, functional consequences, and relationships to disease.

   [Hakon LEFFLER]

   Section MIG (Microbiology, Immunology, Glycobiology), Department Laboratory Medicine, Lund University, Sweden

2. Structural glycobiology approach: A glimpse into the recognition event of glycan-binding protein

   [YoshikiYAMAGUCHI]

   Chemical Biology Department, RIKEN Advanced Science Institute, Japan

3. Structural and molecular basis of carbohydrate-protein interaction systems as potential therapeutic targets

   [Koichi KATO]

   Institute for Molecular Science and Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Japan

4. Systems glycobiology approach for understanding glycan functions in disease

   [Naoyuki TANIGUCHI]

   Systems Glycobiology Research Group, RIKEN Advanced Science Institute and Disease Glycoprobe Team, RIKEN Max Plank Joint Center, Japan

5. Characterization of the galectin family genes of Caenorhabditis elegans: Carbohydrate-binding properties and phenotypes of mutant worms under stress conditions

   [Yoko NEMOTO-SASAKI]

   Department of Biological Chemistry, Teikyo University School of Pharmaceutical Sciences, Japan

6. Molecular mechanism of rhamnose-binding lectin-induced early apoptotic status in Gb3-expressing tumor cells

   [Shigeki SUGAWARA]

   Division of Cell Recognition Study, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Japan

SessionE
Molecular interaction in the domain

1. Membrane functions supported by glycans and glycolipids

   [Akemi SUZUKI]

   Institute of Glycoscience, Tokai University, Japan

2. Regulatory mechanisms of malignant phenotypes of humancancers by tumor-associated carbohydrate antigens in the microdomains

   [Koichi FURUKAWA]

   Department of Biochemistry II, Nagoya University Graduate School of Medicine, Japan

3. Regulation of mammalian glycosylation enzyme expression during human stem cell differentiation

   [Kelley W. MOREMEN]

   Complex Carbohydrate Research Center, University of Georgia, USA

4. Human-specific evolution of siglecs

   [Ajit VARKI]

   Glycobiology Research and Training Center, University of California-San Diego, USA

SessionF
Glycobiology and beyond

1. Trans to cis

   [Akemi SUZUKI]

   Institute of Glycoscience, Tokai University, Japan

2. From snapshots to movies

   [Naoyuki TANIGUCHI]

   Systems Glycobiology Research Group, RIKEN Advanced Science Institute and Disease Glycoprobe Team, RIKEN Max Plank Joint Center, Japan

3. Carbohydrate-based drug discovery and vaccine development

   [Chi-HueyWONG]

   Academia Sinica, Taiwan

4. Glycosylation of lysosomal lipid binding proteins is essential for their function

   [Konrad SANDHOFF]

   LIMES c/o Kekulé-Institut, University of Bonn, Germany

5. Thoughts on the future of glycosciences

   [Ajit VARKI]

   Glycobiology Research and Training Center, University of California-San Diego, USA